Figure 1.

Schematic showing study design. Mice received an orthotopic injection of either PBS (Sham, n = 8) or KPC cells (KPC, n = 9)) into the pancreases (Day 0). Sham mice and KPC mice were then split into either an isotype control (IgG2a) group or an anti-Ly6G Ab treatment group, to deplete Ly6G-expressing cells, including granulocytic MDSCs and neutrophils. Mice were injected with either IgG2a or Ly6G Ab on day 5, 8, 11, and 14, followed by tissue harvest (H) on day 15. Based on comparable changes in body mass and muscle mass throughout study duration, Sham mice receiving IgG2a and Ly6G Ab were subsequently combined into a single control group (Control).