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. 2022 Jun 11;14(12):2885. doi: 10.3390/cancers14122885

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Biomarkers used in the OVA1^® and Overa^® assays developed by Aspira Women’s Health Inc. (A) The OVA1^® assay incorporates TVU findings and menopausal status with changes in serum proteins ApoA-1, B2M, CA125, Transthyretin (Prealbumin) and Transferrin. (B) The Overa^® assay is the second-generation model which incorporates two new serum biomarkers HE4 and FSH, along with three of the original biomarkers defined in the OVA1^® assay. Image was recreated with permission from Aspira Women’s Health [176].