Table 4.

Management recommendations for ircAEs.

ircAE Grade	General Recommendations	Phenotype-Specific Recommendations
1	Start moderate- to high-potency topical corticosteroids Continue ICB	-
2	Consider adding systemic corticosteroids (prednisone 0.5–1 mg/kg daily) Continue ICB	Psoriasiform rash: Consider narrow-band UVB phototherapy or apremilast Pruritus: Consider GABA analogs Bullous Pemphigoid: Hold ICB until grade 0 or 1
3+	Start systemic corticosteroids (prednisone 0.5–2 mg/kg daily) Hold ICB until grades 0–1	Maculopapular or lichenoid rash: Consider infliximab or tocilizumab Psoriasiform rash: Consider ustekinumab, guselkumab, infliximab, adalimumab, apremilast, or retinoids Pruritus: Consider GABA analogs, omalizumab, or dupilumab Bullous Pemphigoid: Consider rituximab SJS/TEN: Hospitalization