Table 3.
Pre- and postoperative grade 3–5 toxicity.
|
Variable |
Preoperative Chemotherapy | Postoperative Chemotherapy | ||||
|---|---|---|---|---|---|---|
| ECX (n = 632) |
EOX (n = 149) |
p-Value | ECX (n = 182) |
EOX (n = 51) |
p-Value | |
| Any grade 3–5 | 422 (67%) | 89 (60%) | 0.105 | 109 (60%) | 26 (51%) | 0.266 |
| Constitutional | 212 (34%) | 39 (26%) | 0.097 | 47 (26%) | 8 (16%) | 0.191 |
| Gastrointestinal | 158 (25%) | 37 (25%) | 0.999 | 39 (21%) | 6 (12%) | 0.160 |
| Hematological | 236 (37%) | 46 (31%) | 0.155 | 66 (36%) | 15 (29%) | 0.409 |
| Vascular | 47 (7%) | 5 (3%) | 0.098 | 4 (2%) | 0 (0%) | 0.579 |
| Other | 120 (19%) | 29 (19%) | 0.908 | 21 (12%) | 4 (8%) | 0.611 |
| Toxicities of specific interest | ||||||
| Diarrhea | 78 (12%) | 24 (16%) | 0.225 | 9 (5%) | 4 (8%) | 0.489 |
| Renal | 12 (2%) | 0 (0%) | 0.137 | 3 (2%) | 0 (0%) | 0.999 |
| Neutropenia | 205 (32%) | 45 (30%) | 0.627 | 64 (35%) | 15 (29%) | 0.505 |
| Thrombocytopenia | 56 (9%) | 9 (6%) | 0.323 | 5 (3%) | 0 (0%) | 0.588 |
| Neuropathy | 5 (1%) | 6 (4%) | 0.009 | 2 (1%) | 2 (4%) | 0.209 |
Hematological included anemia, leucopenia, neutropenia, lymphocytopenia, febrile neutropenia, and thrombocytopenia. Gastrointestinal included mucositis/stomatitis, heartburn/dyspepsia, dysphagia, anorexia, nausea/vomiting, diarrhea, constipation, bowel inflammation, and gastrointestinal fistula/obstruction/perforation. Vascular included cardiac arrhythmia, ischemic event, thromboembolic event, sudden death, and hemorrhage. Constitutional included weight loss, dehydration, dizziness, fatigue, hypertension, infection without neutropenia, insomnia, mood alteration, and pain. Others included allergic/dermatological reaction, alopecia, DPD deficiency, dyspnea, genitourinary obstruction, local complication, metabolic disorder, musculoskeletal disorder, neuro-/ototoxicity, palmar-plantar erythrodysesthesia, psychosis, renal toxicity, and other toxicity.