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. 2022 Jun 20;12(6):859. doi: 10.3390/biom12060859

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Specificity of six selected transcription factors with respect to sinoatrial nodes across three animal species. (A) Plot of z-score normalized specificity measure (SPM) values for three animal species: human on the x-axis, rat on the y-axis, and mouse on the z-axis. Scatter plots showing the relationship between (B) mouse–rat, (C) human–mouse, and (D) human–rat raw SPM values. The dotted lines indicate the threshold SPM values for specificity in this study. SHOX2, HOXA2, and ISL1 exceed the threshold values in all species. SHOX2, HOXA2, and ISL1 exceed the threshold values in all species.