Table 5.
Univariate analyses of prognostic factors for overall survival—T2DM group.
| Variable | HR (95% CI) | p-Value |
|---|---|---|
| Age (years) | 0.978 (0.926–1.033) | 0.426 |
| Gender | - | - |
| Female | Ref | - |
| Male | 0.898 (0.639–1.263) | 0.536 |
| Autoimmune disease | 0.962 (0.334–2.771) | 0.942 |
| Hypertension | 0.732 (0.358–1.500) | 0.393 |
| T | - | - |
| T1 | Ref | - |
| T2 | 0.268 (0.030–2.383) | 0.238 |
| T3 | 0.196 (0.025–1.702) | 0.139 |
| T4 | 0.358 (0.030–4.325) | 0.419 |
| N | - | - |
| N0 | Ref | - |
| N1 | 1.383 (0.465–4.111) | 0.560 |
| N2 | 5.342 (1.264–22.564) | 0.023 |
| M | - | - |
| M0 | Ref | - |
| M1 | 1.524 (0.852–2.725) | 0.156 |
| TNM stage | - | - |
| IA | Ref | - |
| IB | 0.179 (0.017–1.900) | 0.154 |
| IIB | 0.215 (0.025–1.827) | 0.159 |
| III | 0.734 (0.079–6.829) | 0.786 |
| IV | 0.255 (0.029–2.172) | 0.211 |
| Angioinvasion | 2.023 (0.670–6.109) | 0.212 |
| Neuroinvasion | 0.865 (0.194–3.863) | 0.849 |
| R | - | 0.064 |
| R0 | Ref | |
| R1 | 2.185 (0.956–4.996) | |
| Grading | - | - |
| G1 | Ref | - |
| G2 | 2.111 (0.494–9.014) | 0.313 |
| G3 | 1.433 (0.259–7.920) | 0.680 |
| Tumour site | - | - |
| Head | Ref | - |
| Other | 1.705 (0.841–3.454) | 0.139 |
| Operation type | - | - |
| Whipple | Ref | - |
| Other | 1.307 (0.567–3.184) | 0.555 |
| Vascular reconstruction | 0.877 (0.295–2.606) | 0.814 |
| DM treatment | - | - |
| Insulin | Ref | - |
| Metformin | 0.726 (0.363–1.451) | 0.364 |
| Adverse effects—adjuvant chemotherapy | 0.833 (0.237–2.934) | 0.776 |
| Neutropenia | 1.055 (0.376–2.957) | 0.919 |
| Adverse effects—palliative chemotherapy | 0.745 (0.336–1.650) | 0.468 |
| Neutropenia | 0.541 (0.215–1.259) | 0.191 |
| Hepatological | 0.763 (0.228–2.556) | 0.662 |
| Neurological | 0.224 (0.030–1.669) | 0.144 |
| History of other cancers | 1.748 (0.695–4.396) | 0.235 |
| CEA | 1.012 (0.978–1.048) | 0.493 |
| Lymphocytes | 0.964 (0.840–1.107) | 0.607 |
| CRP/lymphocytes ratio | 1.013 (1.004–1.022) | 0.004 |
| Haemoglobin | 0.900 (0.639–1.263) | 0.536 |
| Calcium | 0.738 (0.050–10.854) | 0.825 |
| CRP | 1.018 (1.007–1.028) | <0.001 |
Abbreviations: Ref–reference. Bolded value–value statistically significant.