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. 2022 Jun 10;11(12):1890. doi: 10.3390/cells11121890

Figure 3.

Figure 3

Camkk2 knockout ameliorates high-fat diet (HFD)-induced insulin resistance. (A) Schema for mouse experiment in which TRAMP;Camkk2+/+ (WT) and TRAMP;Camkk2−/− (KO) mice were fed either a normal (ND) or high fat diet (HFD) (15 weeks ND: WT n = 10, KO n = 10; 15 weeks HFD: WT n = 10, KO n = 8; 30 weeks ND: WT n = 10, KO n = 9; 30 weeks HFD: WT n = 10, KO n = 9). (B) Gross morphology and H&E comparison of livers from ND- and HFD-fed TRAMP mice. Raw images and weights of all livers are available in Supplementary File S2. (C–I) Plasma analyses of non-fasted mice. (C) Calculated HOMA-IR* scores, and measured levels of (D) insulin, (E) glucose, (F) total cholesterol (TC), (G) leptin, (H) triglycerides (TG), and (I) free fatty acids (FFA). * p < 0.05, ** p < 0.01, *** p < 0.001; **** p < 0.0001; Two-way ANOVAs.