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. 2022 Jun 10;11(12):1890. doi: 10.3390/cells11121890

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Host Camkk2 ablation decreased cancer cell size and mTOR signaling in TRAMP mice. (A) Individual cell areas and predicted cell volumes for primary tumors derived from 30-week old TRAMP;Camkk2^+/+ and TRAMP;Camkk2^−/− mice described in Figure 4A. (B) Individual cell areas and predicted cell volumes for lung metastases derived from the same TRAMP;Camkk2^+/+ and TRAMP;Camkk2^−/− mice. (C) Representative images (left) and quantification (right) of p-S6 IHC stains (n = 5/group) from tumors in (A) and lung metastases in (B). ns = not significant; * p < 0.05, **** p < 0.0001. For each morphometric analysis, n > 1 × 10⁶ cells/group.