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. 2022 Jun 19;11(12):1966. doi: 10.3390/cells11121966

Figure 1.

Figure 1

Schematic illustration of detection of p16INK4A, p14ARF/p19ARF, p21, and SAβG in selected murine organs during development. P16: p16INK4A; p19: p14ARF/p19ARF. During development, p16INK4A, p14ARF/p19ARF, p21, and SAβG not only mark senescent cells. p16INK4A, p14ARF/p19ARF, and p21 proteins are expressed in distinct cell types during different developmental stages. Expression of the individual proteins correlates with lower expression of proliferation markers in agreement with their classical function as cell cycle inhibitors, with apoptosis, and cellular differentiation. These fundamental processes contribute dynamically to tissue remodeling and morphogenesis during embryonic development.