Figure 2.

Relative positions of the non-homologous regions—NHR1-1, NHR3-1, NHR5-1 and NHR5-2—in the Prs2 polypeptide as the prototype. The Prs2 polypeptide consists of 318 aa and is indicated as an open bar with characteristic motifs therein. PP = pyrophosphate. The NHRs are positioned in Prs2 as triangles above or below the open bar. The coordinates of the four insertions reflect their lengths in Prs1, Prs3 and Prs5, respectively. The insertion points are defined where the similarity between Prs2 and Prs1 or Prs5 falls off. Sequence comparison was performed using the pairwise sequence alignment programme EMBOSS Needle.