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. 2022 Jun 13;11(12):1909. doi: 10.3390/cells11121909

Figure 7.

Figure 7

Influence of genocopies p.L115T and p.Q133P in ScPrs1, which correspond to the human neuropathies CMTX5 (p.M115T) and Arts syndrome (p.Q133P), respectively, and characteristic motifs of Prs1 either singly or in combination: H130A, divalent cation-binding site; D326A, PRPP-binding site/Ribose-5-phosphate binding site. It should be noted that the locations of the mutations H130A and D326A differ from those in Figure 2, since the length of Prs1 (427 aa) is increased with respect to Prs2 (318 aa) on account of the insertion of NHR1-1; (a) on Rlm1 expression following incubation at 30 °C and 37 °C, all values are significantly different from the WT at p < 0.001 (n = 12-20); (b) on PRS activity. p-values: * = p ≤ 0.05; ** = p ≤ 0.05, ns = not significant.