Table 2.
Count of peripheral lymphocytes, CD3+, CD4+ and CD8+ subsets, CD40L in CD45+CD4+RO+ (expressed as percentage), and count of CD45+CD4+RO+ and CD45+CD8+RO+ expressing TNFα and IFNγ in CVID study groups. Values are reported as median (IQR).
| CVID (All) n = 47 |
NR n = 17 |
S1 IgG R n = 19 |
S1 IgG/IgA R n = 11 |
HD n = 9 |
|
|---|---|---|---|---|---|
| Lymphocytes (cells/mm3) |
1400 (1070–1930) |
1170 (525–1375) |
1870 (970–2470) |
1550 (1420–1770) |
2530 (2438–2775) |
| CD3+ (cells/mm3) |
1112 (758–1617) |
863 (451–1198) |
1280 (738–1930) |
1112 (966–1314) |
1960 (1767–2119) |
| CD3+CD4+ (cells/mm3) |
641 (470–876) |
490 (243–636) |
641 (470–998) |
876 (749–1127) |
1518 (1311–1664) |
| CD4+ naive (cells/mm3) |
107 (33–229) |
32 (14–194) |
107 (53–201) |
241 (87–395) |
791 (600–997) |
| CD4+ central memory (cells/mm3) | 146 (89–201) |
109 (55–161) |
140 (121–216) |
173 (64–291) |
376 (238–418) |
| CD4+ naïve/memory ratio | 0.76 (0.41–1.05 |
0.56 (0.305–1.055) |
0.78 (0.62–1.15) |
0.83(0.55–1.05) | 3.07 (2.855–5.07) |
| CD40L expression in CD45RO+CD4+ cells (%) | 23.4 (14–36.7) |
24.7 (12.8–33.95) |
20.1 (9.9–26.9) |
42.8 (23.4–51.8) |
58.8 (50.9–62.4) |
| TNFα CD45RO+CD4+ (cells/mm3) | 68.5 (37.2–98.4) |
66.8 (30.5–98) |
55.4 (31.3–77) |
75.5 (66.2–117.9) |
152.8 (91.7–233.5) |
| IFNγ CD45RO+CD4+ (cells/mm3) | 27 (8.5–51.3) |
29 (9.8–59.7) |
10.1 (5.6–35.3) |
34.3 (15.7–52.3) |
48 (23–113.6) |
| CD3+CD8+ (cells/mm3) |
542 (333–804) |
482 (210.5–693.5) |
736 (333–1106) |
461 (382–579) |
778 (730–1033) |
| CD8+ naive (cells/mm3) |
64 (31–117) |
28 (12–56.5) |
85 (34–117) |
106 (68–134) |
431 (313.5–496) |
| CD8+ central memory (cells/mm3) | 19 (10–33) |
17 (9.5–30.5) |
24 (13–38) |
19 (10–36) |
19 (11.5–27) |
| CD8+ naïve/memory ratio | 0.76 (0.41–1.05) |
0.11 (0.06–0.24) |
0.23 (0.11–0.3) |
0.47 (0.27–0.63) |
1.23 (0.71–2.61) |
| CD40L expression in CD45RO+CD8+ cells (%) | 2.6 (0.9–6.1) |
3.4 (1.35–7.5) |
3.0 (1.5–12.9) |
13.5 (4.1–18.3) |
7.2 (4.8–10.5) |
| TNFα CD45RO+CD8+ (cells/mm3) | 42 (24.7–79.8) |
59.7 (22.75–94.25) |
48.1 (34.5–82.6) |
24.8 (20.7–49.8) |
15.1 (11.05–26.25) |
| IFNγ CD45RO+CD8+ (cells/mm3) |
42.7 (22.8–97) |
63.4 (23.95–133.0) |
42.4 (33.4–91.1) |
22.8 (12.2–59.7) |
24.4 (8.85–33.7) |