Table 3.

Summary of immune alterations and clinical conditions relevant to the lack of antibody response to SARS-CoV-2 immunization in CVID.

Peripheral blood Lymphocyte counts	Reduced
Circulating B cells	Reduced
Switched memory B cells	Reduced
Circulating CD4 T cells	Reduced
Circulating Naive CD4 and CD8 T cells	Reduced
CD40L expression in stimulated CD4+CD45+RO+	Reduced
TNFα and IFNγ expressing CD8+ cells	Increased
IFNγ release by SARS-CoV-2-induced CD4+ T-cells	Reduced
Chronic Lung disease, Bronchiectasis	Increased
Autoimmune cytopenias	Increased