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. 2022 Jun 16;11(12):1945. doi: 10.3390/cells11121945

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Proposed tree topology of HSP70/HSC70 family members in metazoans (adapted from Yu et al. [32]). Red and green circles show the nodes that give birth to Lineage A of invertebrate HSP70s (clade 1) and Lineage B of both vertebrate and invertebrate HSP70s and all HSC70 genes, respectively. This second lineage has further diversified within diverse phyla: Platyhelminthes (clade 2), Rotifera (clade 3), Nematoda (clade 4), and Chordata (clade 5). Clades 1 to 6 include only cytosolic members of the HSP70 family.