Table 2.
Multivariable analyses of Cancer-Specific Survival in the training cohort.
| Variable | Multivariate Analysis | ||
|---|---|---|---|
| HR | 95% CI | p Value | |
| Race | |||
| Black | Reference | ||
| White | 0.859 | 0.703–1.049 | 0.135 |
| Other | 0.985 | 0.746–1.300 | 0.914 |
| Sex | |||
| Female | Reference | ||
| Male | 1.065 | 0.917–1.238 | 0.407 |
| Primary site | |||
| RCC | Reference | ||
| LCC | 0.574 | 0.476–0.691 | <0.0001 |
| RC | 0.614 | 0.504–0.748 | <0.0001 |
| Histology | |||
| Adenocarcinoma (Ad) | Reference | ||
| Mucinous adenocarcinoma (Mu) | 0.938 | 0.672–1.309 | 0.704 |
| Other | 1.578 | 1.008–2.471 | 0.046 |
| Grade | |||
| Well + moderately (w + m) | Reference | ||
| Poorly + undifferentiated (p + u) | 1.938 | 1.637–2.294 | <0.0001 |
| Stage_T | |||
| T0-1 | Reference | ||
| T2 | 0.793 | 0.452–1.392 | 0.419 |
| T3 | 0.781 | 0.596–1.023 | 0.073 |
| T4 | 1.042 | 0.794–1.368 | 0.766 |
| Stage_N | |||
| N0 | Reference | ||
| N1 | 1.019 | 0.829–1.254 | 0.856 |
| N2 | 1.405 | 1.120–1.763 | 0.003 |
| Stage_M | |||
| M1a | Reference | ||
| M1b | 1.624 | 1.352–1.952 | <0.0001 |
| Surgery (PTMR) | |||
| Neither (none) | Reference | ||
| Primary+ metastatic (yes) | 0.378 | 0.291–0.490 | <0.0001 |
| Only primary | 0.567 | 0.452–0.712 | <0.0001 |
| Only metastatic | 0.642 | 0.363–1.133 | 0.126 |
| Extrahepatic metastasis (met) | |||
| No | Reference | ||
| Yes | 1.222 | 0.982–1.521 | 0.072 |
| CEA | |||
| Positive | Reference | ||
| Negative | 0.773 | 0.633–0.943 | 0.011 |