Table 2.
Effects of ascorbic acid on hepatic enzymes in male rats after 30 days of administration of either azithromycin or etoricoxib or their combinations.
| ALT (U/L) | AST (U/L) | |||||
|---|---|---|---|---|---|---|
| 1st Day | 14th Day | 30th Day | 1st Day | 14th Day | 30th Day | |
| Control Azithromycin (AZO) |
13.02 ± 0.87 d | 14.02 ± 1.02 d | 13.02 ± 1.02 e | 14.36 ± 1.69 d | 13.69 ± 2.02 f | 14.01 ± 1.69 ef |
| 3.02 ± 1.87 d | 63.02 ± 2.87 c** | 141.02 ± 5.87 b*** | 23.02 ± 0.87 b** | 53.02 ± 0.87 b** | 83.02 ± 0.87 c** | |
| Etoricoxib (ETO) | 34.25 ± 2.36 a** | 88.65 ± 2.65 b** | 120.36 ± 2.65 c*** | 20.36 ± 1.69 c | 44.36 ± 1.69 c** | 87.65 ± 2.05 bc** |
| Ascorbic acid (AS) | 13.25 ± 1.25 d | 12.69 ± 1.39 d | 12.58 ± 1.63 e | 15.99 ± 1.85 d | 14.25 ± 1.36 ef | 12.69 ± 1.69 f |
| AZO + ETO | 28.36 ± 3.21 b* | 98.69 ± 2.01 ab** | 189.25 ± 1.69 a*** | 29.67 ± 2.69 a* | 78.25 ± 2.01 a*** | 110.98 ± 2.69 a*** |
| AZO + ETO + AS | 21.36 ± 1.25 c* | 67.36 ± 2.01 c** | 47.02 ± 2.36 d** | 21.36 ± 2.03 c* | 35.35 ± 1.47 d** | 69.15 ± 1.69 d** |
Results are expressed as mean ± SE. Mean values with different letters in the same row show significance at p ≤ 0.05, where the highest mean value has the symbol a and b,c,d,f: For significance: * for p < 0.05, or ** for p < 0.01, or *** for p < 0.001. AZO: Azithromycin, ETO: Etoricoxib, AS: Ascorbic acid, ALT: Alanine aminotransferase, AST: Aspartate aminotransferase, LDH: Lactate dehydrogenase enzyme.