Table 4.
Effects of ascorbic acid on oxidative stress enzymes and oxidative damage markers in hepatic tissues in male rats after administration of either azithromycin or etoricoxib or their combinations after 30 days post administration.
| Parameters | Control | AZO | ETO | AS | AZO + ETO | AZO + ETO + AS |
|---|---|---|---|---|---|---|
| CAT (U/g) | 11.02 ± 0.26 a | 2.42 ± 0.16 c*** | 1.57 ± 0.76 c*** | 11.98 ± 2.25 | 1.98 ± 0.87 *** | 8.52 ± 1.69 ** |
| SOD (U/g) | 16.20 ± 0.26 a | 10.07 ± 0.45 c*** | 8.17 ± 1.45 c*** | 17.02 ± 2.25 | 7.05 ± 1.58 *** | 13.82 ± 0.34 a** |
| GSH (U/g) | 15.78 ± 2.38 b | 8.10 ± 0.88 c** | 6.80 ± 1.88 c** | 16.25 ± 1.58 | 5.25 ± 0.58 ** | 12.12 ± 0.33 ab** |
| MDA (µg/mg) | 3.01 ± 0.15 cd | 14.01 ± 1.30 a*** | 15.41 ± 1.80 a | 2.01 ± 0.58 | 30.25 ± 2.02 *** | 7.05 ± 0.68 d** |
Results are expressed as mean ± SE. Mean values with different letters in the same row show significance at p ≤ 0.05, where the highest mean value has the symbol a and b,c: For significance: ** for p < 0.01, or *** for p < 0.001. AZO: Azithromycin, ETO: Etoricoxib, AS: Ascorbic acid, CAT: Catalase, SOD: Superoxide dismutase, GSH: Glutathione, MDA: Malondialdehyde.