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. 2022 Jun 16;11(12):1936. doi: 10.3390/cells11121936

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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EGFR and TP-activation triggers a qualitative but no quantitative synergistic regulation after 48 h. (a) Overlap of the lists of DEG after 48 h incubation. (b) Histograms and density curves for the log2-fold changes (calculated by edgeR) of the genes comprised in the intersection of the Venn Diagram. (left graph: down-regulated genes, right graph: up-regulated genes). The dotted lines correspond to the mean. The Kolmogorov–Smirnov test was used to assess if the shifts in distribution were statistically significant.