Table 2.
Quantitative synergistic effect on gene expression. FPM comparison highlighted genes for which the incubation with combined substances led to a significant increase in the effect magnitude. Genes with p < 0.05 (t-test) when comparing EGF to “EGF and U46619” and U46619 to “EGF and U46619” were selected. “Substances” and “regulation” columns indicate which combination triggered a synergistic effect and in which direction.
| Gene | Ensemble Identifier | Intersection | Substances | Regulation |
|---|---|---|---|---|
| Ctdsp1 | ENSMUSG00000026176 | i1 | EGF, U46619 | Down |
| Fam110b | ENSMUSG00000049119 | i5 | EGF, U46619 | Down |
| Gm6665 | ENSMUSG00000091561 | i17 | EGF, U46619 | Down |
| Gstm2 | ENSMUSG00000040562 | i17 | EGF, U46619 | Down |
| Hadhb-ps | ENSMUSG00000063684 | i1 | EGF, U46619 | Down |
| Inpp4a | ENSMUSG00000026113 | i1 | EGF, U46619 | Down |
| Klf15 | ENSMUSG00000030087 | i7 | EGF, U46619 | Down |
| Mtap | ENSMUSG00000062937 | i1 | EGF, U46619 | Up |
| Pcif1 | ENSMUSG00000039849 | i1 | EGF, U46619 | Down |
| Spp1 | ENSMUSG00000029304 | i17 | EGF, U46619 | Up |
| Srr | ENSMUSG00000001323 | i6 | EGF, U46619 | Down |
| Tpst1 | ENSMUSG00000034118 | i1 | EGF, U46619 | Down |