Table 2.
Association of Trop-2 expression with clinicopathological characteristics of upper tract urothelial carcinoma.
| Variable | n | Trop-2 expression | p | |||||
|---|---|---|---|---|---|---|---|---|
| 0 + (%) | 1 + (%) | 2 + (%) | 3 + (%) | 0 vs. 1 +/2 +/3 + | 0/1 + vs. 2 +/3 + | 0/1 +/2 + vs. 3 + | ||
| Sex | 0.077 | 0.37 | 0.82 | |||||
| Male | 60 | 1 (1.7) | 15 (25.0) | 26 (43.3) | 18 (30.0) | |||
| Female | 39 | 4 (10.3) | 10 (25.6) | 16 (41.0) | 9 (23.1) | |||
| Tumor site | 0.37 | 0.66 a | 0.82 a | |||||
| Renal pelvis | 45 | 1 (2.2) | 12 (26.7) | 20 (44.4) | 12 (26.7) | |||
| Ureter | 50 | 4 (8.0) | 13 (26.0) | 20 (40.0) | 13 (26.0) | |||
| Both | 4 | 0 (0.0) | 0 (0.0) | 2 (50.0) | 2 (50.0) | |||
| Tumor grade | 0.57 | 0.54 | 1.00 | |||||
| Low-grade | 15 | 1 (6.7) | 2 (13.3) | 8 (53.3) | 4 (26.7) | |||
| High-grade | 84 | 4 (4.8) | 23 (27.4) | 34 (40.5) | 23 (27.4) | |||
| Pathological stage | 0.65 b | 1.00 b | 0.020 b ** | |||||
| pTa | 19 | 1 (5.3) | 5 (26.3) | 4 (21.1) | 9 (47.4) | |||
| pT1 | 18 | 0 (0.0) | 5 (27.8) | 7 (38.9) | 6 (33.3) | |||
| pT2 | 8 | 0 (0.0) | 2 (25.0) | 4 (50.0) | 2 (25.0) | |||
| pT3 | 48 | 3 (6.3) | 12 (25.0) | 24 (50.0) | 9 (18.8) | |||
| pT4 | 6 | 1 (16.7) | 1 (16.7) | 3 (50.0) | 1 (16.7) | |||
| Lymphovascular invasion | 0.39 | 1.00 | 0.069 | |||||
| No | 59 | 2 (3.4) | 16 (27.1) | 21 (35.6) | 20 (33.9) | |||
| Yes | 40 | 3 (7.5) | 9 (22.5) | 21 (52.5) | 7 (17.5) | |||
| Lymph node involvement | 0.075 c | 0.74 | 0.50 c | |||||
| pN0 | 84 | 2 (2.4) | 22 (26.2) | 35 (41.7) | 25 (29.8) | |||
| pN+ | 12 | 2 (16.7) | 2 (16.7) | 6 (50.0) | 2 (16.7) | |||
| pNx | 3 | 1 (33.3) | 1 (33.3) | 1 (33.3) | 0 (0.0) | |||
a Renal pelvis vs. ureter; b pTa + pT1 vs. pT2 + pT3 + pT4; c pN0 vs. pN+; ** p < 0.05.