Table 4.

Univariate and multivariate analyses of progression-free survival and cancer-specific survival in patients with high-risk upper tract urothelial carcinoma.

	Progression-Free Survival						Cancer-Specific Survival
Variable	Univariate			Multivariate			Univariate			Multivariate
	HR	95 %CI	p	HR	95 %CI	p	HR	95 %CI	p	HR	95 %CI	p
High-risk group † (n = 60)
Sex (male/female)	1.35	0.67–2.72	0.40				1.23	0.58–2.65	0.6
Age (70</≤70) years	1.11	0.56–2.18	0.77				1.57	0.73–3.37	0.24
Tumor site (pelvis/ureter)	0.95	0.48–1.91	0.89				0.97	0.46–2.04	0.93
Tumor grade (high/low)	6.96	0.95–51.06	0.056 *	7.91	1.07–58.25	0.042 **	6.41	0.87–47.47	0.069 *	7.09	0.96–52.49	0.055 *
Adjuvant chemotherapy (Yes/No)	0.71	0.35–1.46	0.36				0.63	0.28–1.41	0.26
Trop-2 strong expression	0.30	0.092–0.99	0.048 **	0.268	0.081–0.88	0.031 **	0.29	0.069–1.23	0.093 *	0.26	0.061–1.10	0.067 *

^† High-risk group is defined as patients with a pathologic stage of ≥pT3 or positive lymphatic invasion or lymph node metastasis; ** p < 0.05 and * p < 0.1. Abbreviations: CI, confidence interval; HR, hazard ratio.