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. 2022 Jun 1;13(6):997. doi: 10.3390/genes13060997

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Reducing AKR1C3 expression in thyroid cancer cells inhibits proliferation, migration and invasion: (A) TPC-1 and 8505c cell lines were transfected with siNC or siAKR1C3, and the level of PHLPP1 mRNA expression was assessed by RT-qPCR; (B,C) the CCK-8 assays indicated that knockdown of AKR1C3 inhibits cells proliferation in TPC-1 and 8505c; (D–G) the wound-healing and transwell asssays suggested that AKR1C3 reduces cell migration and invasion in TPC-1 and 8505c (** p < 0.01, *** p < 0.001).