Fig. 3.

Receiver-operator curves (ROC) for the best-performing versions of the susceptibility and hospitalization PRS.

Area under the ROC (AUC) are shown for logistic regression models including age, sex, and PRS, as well as models with only one of the predictors in the testing dataset. A) Performance of susceptibility PRS including SNPs associated with SARS-CoV-2 infection at P <0.5 (PRS1a) in testing dataset of 37 cases and 28 controls. B) Performance of severity PRS including SNPs associated with hospitalization at P <0.1 (PRS3b) in testing dataset of 24 hospitalized and 13 ambulatory cases.