Table 3.
Association of human genetic variants with susceptibility to COVID-19 and phenotype severity.
| Gene | SNP ID | Susceptibility |
Susceptibility (1kGP) |
Hospitalization |
Severity |
Ambulatory vs. severe disease |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genetic model | ORadj (95% CI) | padj | Genetic model | OR (95% CI) | p | Genetic model | ORadj (95% CI) | padj | Genetic model | ORadj (95% CI) | padj | Genetic model | ORadj (95% CI) | padj | ||
| LZTFL1 | rs73064425 C/T | Overdominant (CT) | 3.24 (1.16 - 8.99) | 0.020 | Allelic (T) | 1.92 (1.20 - 3.07) | 0.006 | Log-additive (T) | 7.75 (2.1 - 28.55) | 0.0004 | Log-additive (T) | 5.78 (1.66 -20.14) | 0.003 | Log-additive (T) | 78.36 (4.16 – Inf) | 2.26 × 10−5 |
| CCL2 | rs1024611 A/G | Allelic (G) | 0.56 (0.39 - 0.78) | 0.001 | ||||||||||||
| APOE | rs7412 C/T | Allelic (T) | 4 (1.3 - 12.33) | 0.006 | Log-additive (T) | 3.16 (1.1 - 9.04) | 0.030 | |||||||||
| APOE | rs429358 C/T | Recessive (CC) | 1 (1-1) | 0.042 | ||||||||||||
| ABO | rs657152 A/C | Recessive (AA) | 1 (1-1) | 0.020 | ||||||||||||
| FURIN | rs4702 A/G | Dominant (AG – GG) | 0.43 (0.19 - 0.95) | 0.036 | Allelic (G) | 0.74 (0.56 - 0.99) | 0.042 | Recessive (GG) | 9.10 (1.25 - 66.18) | 0.022 | ||||||
| NOTCH4 | rs3131294 A/G | Log-additive (A) | 3.6 (1.14 - 11.4) | 0.016 | Log-additive (A) | 5.23 (0.97 - 28.16) | 0.034 | |||||||||
| DPP9 | rs2109069 G/A | Log-additive (A) | 2.61 (1.07 - 6.37) | 0.030 | ||||||||||||
| IL6 | rs1800795 C/G | Overdominant (CG) | 0.34 (0.11 - 1.01) | 0.049 | ||||||||||||
| OAS1 | rs1131454 A/G | Codominant (AG / GG) | AG: 0.57 (0.36 - 0.89)GG: 0.89 (0.52 - 1.52) | 0.035 | ||||||||||||
OR = odds ratio. 95% CI = 95% confidence interval. adj = P-value, OR and 95% CI after adjustment for age and sex in the logistic regression model. P-values which remained significant after Bonferroni correction are indicated in bold. 1kGP = 1000 genomes project. LZTFL1 = leucine zipper transcription factor like 1. APOE = Apoprotein E. ABO = ABO blood group (Alpha 1-3-N-Acetylgalactosaminyltransferase and Alpha 1-3-Galactosyltransferase). FURIN = Furin (Paired Basic Amino Acid Cleaving Enzyme). NOTCH4 = Notch Receptor 4. CCL2 = C-C Motif Chemokine Ligand 2. DPP9 = Dipeptidyl-Peptidase 9. IL6 = Interleukin-6. OAS1 = 2′-5′-Oligoadenylate Synthetase 1.