Table 1.

Compositions of preliminary batches of nasal in situ gel of darunavir.

Composition	F1	F2	F3	F4	F5	F6	F7	F8	F9
Darunavir (%)	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2
PEG 400 + PEG 6000 (%)	15 + 15	15 + 15	15 + 15	15 + 15	15 + 15	15 + 15	15 + 15	15 + 15	15 + 15
Poloxamer 407 (%)	18	18	18	20	20	20	22	22	22
Carbopol 934P (%)	0.1	0.3	0.5	0.1	0.3	0.5	0.1	0.3	0.5
Methyl paraben (%)	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05
Distilled water (%)	Up to 100	Up to 100	Up to 100	Up to 100	Up to 100	Up to 100	Up to 100	Up to 100	Up to 100