Table 1. Sequence alignments of C. albicans and human Tor kinases.
| Region | Ca.Tor1 8 N-terminal HEAT repeats |
N-HEAT | Middle HEAT | FAT | FRB | Kinase Domain |
|---|---|---|---|---|---|---|
| Identity | 123/479 (25.7%) |
287/932 (30.8%) |
116/281 (41.3%) |
293/674 (43.5%) |
50/96 (52.1%) |
315/559 (56.4%) |
| Similarity | 213/479 (44.5%) |
453/932 (48.6%) |
199/281 (70.8%) |
409/674 (60.7%) |
74/96 (77.1%) |
401/559 (71.7%) |
| Gaps | 130/479 (27.1%) |
182/932 (19.5%) |
5/281 (1.8%) |
53/674 (7.9%) |
0/96 (0.0%) |
42/559 (7.5%) |
| Aa residues Ca.Tor1 | 1–381 | 22–853 | 909–1187 | 1310–1951 | 1972–2067 | 1952–2481 |
| Aa residues Hs.mTor | 1–447 | 25–874 | 942–1219 | 1350–2002 | 2023–2118 | 2003–2548 |
Individual regions of Tor kinase from C. albicans (Ca.Tor1) and human (Hs.mTOR) were aligned and compared using EMBOSS Needle Pairwise Sequence Alignment (https://www.ebi.ac.uk/Tools/psa/emboss_needle/). Boundaries of each region were chosen according to the amino acid sequence alignment in Fig A of S1 Text.