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Schema of the in vivo studies. In the spinal root injury, treatment was given from the surgery until 42 days, when samples of the spinal cord were obtained. In the SOD1G93A mice, EST79232 and EST79376 were given from 8 to 16 weeks of age. Electrophysiological and rotarod tests were performed periodically until 16 weeks, when samples of spinal cord and muscle were harvested.
