Table 1.

Plasma levels of EST79232, EST79376, and PRE-084 after chronic intraperitoneal administration.

Model	Compound	Dose (mg/kg)	Plasma Concentration (ng/mL)15 min Post-Administration
			Mean	SD
Spinal Nerve Injury female mouse	EST79232	0.5	20	8
		5	265	53
	EST79376	0.5	21	7
		5	592	176
	PRE-084 a	0.25	3.6	0.8
Transgenic SOD1G93A male mouse	EST79232	5	425	129
	EST79376	5	692	206
	PRE-084 a	0.25	2.6	1.3

^a: Concentrations determined at 30 min post-administration. Data obtained in a separate study.