Table 1.

Genes reported to alter depending on osteoarthritis (OA) pathology.

Gene Name	Normal Chondrocyte Cell (vs. OA-Induced Cell) ¶	Predicted Alterations by Secretome vs. Literature $	Reference
MMP3	−	Mat.	[25,26]
MMP13	−	Mat.	[20]
ADAMTS5	−	Opp.	[25]
Caspase9	−	Mat.	[27]
Bax	−	Mat.	[28,29]
Bcl-2	N.C	Mat.	[30]
COL2a1	+	Mat.	[23,25]
ACAN	+	Mat.	[23]
SOX9	+	N.D	[23]
HIF1α	+	Opp.	[31]
TNFα	−	Mat.	[32]
IL-1β	−	N.D	[33]
IL-4	+	Mat.	[34]
TGFβ	−	Mat.	[24]
COL1a1	−	Opp.	[23]
BMP2	−	N.D	[23]
RUNX2	−	Opp.	[23,35]
COL10a1	−	N.D	[23,36]
IHH	−	Mat.	[23,37]
DKK1	+	N.D	[23,38,39]
FRZB	+	N.D	[23]
GREM1	+(early)/−(late)	N.D	[23]
AXIN2	−	N.D	[23]
TIMP1	+	Mat.
IL-6	−	Mat.	[21,22,40]
LIF	−	N.D
IL-17	−	Mat.	[33]
MMP1	−	Mat.	[20,25]
NF-kB	−	Opp.	[22,41]
STAT3	−	Opp.	[21,42]

¶, The expression levels of genes in normal chondrocyte cells compared to osteoarthritis-differentiated cells reported in the literature. + indicates that the gene level was higher in normal cells than in OA-differentiated cells. − indicates the opposite case. $, Comparison between the expression levels in normal chondrocytes reported by other studies and the predicted levels based on our secretome profile using IPA tool; N.C., no change; Mat., IPA-predictions matched to literature; Opp., IPA-prediction contradictory the literature; N.D., no decision.