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LepR∆SOCS3 mice are protected against aging-induced leptin resistance. Twenty-four hour food intake after an i.p. injection of PBS or leptin (2.5 µg/g body weight) in young adult (3-month-old) control (n = 6) and LepR∆SOCS3 (n = 7) mice and in middle-aged (15-month-old) control (n = 7) and LepR∆SOCS3 (n = 4) mice. Mean ± SEM. * p < 0.05 control vs. LepR∆SOCS3 (post-hoc test repeated measures two-way ANOVA).
