TABLE 1.
Demographic Characteristics, Medical History, Cardiorespiratory Indices, and Risk Indicators of Study Patients Across Tertiles of CAC
| Degree of CAC in Study Population | ||||
|---|---|---|---|---|
| Tertile 1 (n=25) | Tertile 2 (n=23) | Tertile 3 (n=23) | P for Difference | |
| Age, median (IQR) (y) | 57 (14) | 67 (11) | 73 (5) | <0.001 |
| Sex, men | 72.0 | 78.2 | 78.2 | 0.840 |
| Length of ICU stay, median (IQR) (d) | 18.0 (17.0) | 22.0 (25.0) | 15.0 (15.5) | 0.177 |
| ICU mortality | 24.0 | 30.4 | 52.2 | 0.481 |
| Height, median (IQR) (cm) | 180 (15.0) | 175 (10.0) | 173 (8.5) | 0.082 |
| Weight, median (IQR) (kg) | 90 (20.0) | 83 (12.5) | 80 (13.3) | 0.330 |
| Body mass index (kg/m2), median (IQR) | 27.8 (4.0) | 27.1 (3.5) | 27.1 (5.4) | 0.852 |
| Chronic cardiac disease | 0.0 | 0.0 | 4.3 | 0.648† |
| Chronic pulmonary disease | 4.0 | 8.7 | 13.0 | 0.508† |
| Chronic kidney disease | 4.0 | 0.00 | 0.00 | 1.000† |
| Liver disease | 0.0 | 0.0 | 4.3 | 0.648† |
| Diabetes mellitus type 2 | 8.0 | 0.0 | 26.1 | 0.015† |
| Presence of cardiovascular risk factors | ||||
| Hypertension | 20.0 | 31.8 | 47.8 | 0.121 |
| Dyslipidemia | 4.0 | 18.2 | 39.1 | 0.010† |
| Smoking | 8.0 | 9.1 | 13.0 | 0.888† |
| Obesity | 8.0 | 4.5 | 21.7 | 0.197 |
| APACHE II score, median (IQR) (points) | 15.0 (4.0) | 15.0 (4.5) | 18.0 (6.5) | 0.052 |
| SOFA score on admission, median (IQR) | 5.0 (4.0) | 6.0 (3.0) | 7.0 (4.0) | 0.211 |
| Mechanical ventilation, yes | 88.0 | 95.5 | 95.7 | 0.610† |
| Pressure control | 44.0 | 56.5 | 60.7 | |
| Pressure support | 8.0 | 4.3 | 4.3 | |
| CPAP | 36.0 | 30.4 | 30.4 | |
| FiO2 high admission, median (IQR) | 80.0 (35.0) | 70.0 (23.8) | 70.0 (25.0) | 0.163 |
| Respiration rate high on admission, median (IQR) (per min) | 30.0 (12.0) | 26.0 (3.5) | 25.0 (4.5) | 0.149 |
| Inspiratory pressure, median (IQR) (cm H2O) | 20.0 (8.0) | 24.0 (10.0) | 24.0 (9.3) | 0.258 |
| Positive end-expiratory pressure (cm H2O) | 29.3 (±5.0) | 29.2 (±1.8) | 27.0 (±4.5) | 0.513* |
| Tidal volume, median (IQR) (mL) | 497.0 (155.0) | 464.0 (114.0) | 437.0 (93.0) | 0.609 |
| Arterial blood gas PO2, median (IQR) (kPa) | 10.5 (4.5) | 9.2 (3.2) | 9.6 (2.0) | 0.440 |
| Arterial blood gas PCO2, median (IQR) (kPa) | 5.0 (2.3) | 6.2 (1.6) | 5.2 (1.5) | 0.295 |
| Arterial blood gas, median (IQR) (pH) | 7.34 (0.15) | 7.29 (0.22) | 7.29 (0.14) | 0.487 |
| Mean arterial pressure (mm Hg) | 100.4 (±14.0) | 99.7 (±13.3) | 96.8 (±13.5) | 0.629* |
| Vasopressor use, yes | 40.0 | 65.2 | 78.3 | 0.022 |
| Bilirubin, median (IQR) (µg/L) | 9.4 (5.8) | 10.5 (5.5) | 9.6 (10.8) | 0.795 |
| Dialysis, yes | 12.0 | 8.7 | 21.7 | 0.481† |
| Creatinine, median (IQR) (µmol/L) | 77.0 (30.0) | 72.0 (37.0) | 80.0 (95.3) | 0.758 |
| Urine production, median (IQR) (mL/24 h) | 1350 (1230) | 1590 (1615) | 630 (1118) | 0.017 |
| Glasgow Coma Score, median (IQR) | 15 (0) | 15 (0) | 15 (0) | 0.062 |
| Thrombocytes, median (IQR) (109/L) | 330.5 (108.5) | 374.0 (140.0) | 254.0 (131.0) | 0.031 |
Data are presented as mean (±SD) or count (%), unless indicated otherwise. Differences were tested using the independent-samples t test or Pearson χ2test, unless indicated otherwise.
*
One-way analysis of variance instead of Kruskal-Wallis test.
†
Fisher exact test instead of χ2 test due to low expected values.
CPAP indicates continuous positive airway pressure; FiO2, fraction of inspired oxygen; PCO2, partial pressure of carbon dioxide; PO2, partial pressure of oxygen.