TABLE 3.

Results of Linear Mixed-effect Models: Development of Individual SOFA Component Scores

	Model 2		Model 4
	Adjusted Regression Coefficient (95% CI)	P	Adjusted Regression Coefficient (95% CI)	P
Tertile 1, degree of CAC in the study population	Reference		Reference
PaO2/FiO2 ratio
Tertile 2	−0.02 (−0.10 to 0.06)	0.707	−0.01 (−0.10 to 0.08)	0.829
Tertile 3	−0.03 (−0.12 to 0.06)	0.500	−0.03 (−0.10 to 0.08)	0.564
PaO2 (kPa)
Tertile 2	−0.41 (−0.97 to 0.16)	0.154	−0.40 (−0.95 to 0.14)	0.145
Tertile 3	−0.28 (−0.92 to 0.36)	0.393	−0.36 (−1.03 to 0.31)	0.285
FiO2 (%)
Tertile 2	2.67 (−3.38 to 8.72)	0.382	2.20 (−3.59 to 7.99)	0.451
Tertile 3	1.64 (−4.97 to 8.26)	0.622	1.68 (−5.05 to 8.41)	0.620
SOFA cardiovascular component score
Tertile 2	0.38 (−0.12 to 0.88)	0.135	0.38 (−0.15 to 0.90)	0.155
Tertile 3	0.33 (−0.21 to 0.87)	0.226	0.49 (−0.10 to 1.09)	0.106
Bilirubin (μmol/L)
Tertile 2	−0.75 (−5.55 to 4.05)	0.756	−2.17 (−6.95 to 2.61)	0.370
Tertile 3	2.01 (−3.25 to 7.27)	0.449	1.23 (−4.31 to 6.77)	0.660
SOFA renal component score
Tertile 2	−0.04 (−0.73 to 0.65)	0.913	−0.21 (−0.89 to 0.47)	0.537
Tertile 3	0.62 (−0.13 to 1.38)	0.104	0.40 (−0.39 to 1.19)	0.315
Glasgow Coma Score
Tertile 2	−0.07 (−0.20 to 0.07)	0.343	−0.54 (−1.60 to 0.52)	0.317
Tertile 3	−0.03 (−0.18 to 0.12)	0.660	−0.54 (−1.79 to 0.71)	0.390
Thrombocytes (109/L)
Tertile 2	39.5 (−28.2 to 107.2)	0.250	26.6 (−42.2 to 95.4)	0.444
Tertile 3	−53.9 (−130 to 22.2)	0.163	−40.1 (−121.8 to 41.7)	0.333

Data are longitudinal regression coefficients that show the average difference per SOFA score component over time between CAC (CAC) tertiles, with the lowest CAC tertile as the reference category. Data are adjusted for age, sex, and APACHE II score (Model 2) and additionally for chronic liver, lung, and renal disease (Model 4).

CI indicates confidence interval; FiO₂, fraction of inspired oxygen; PaO₂, partial pressure of oxygen.