Table 2.

Molecular regulation of PARK7/DJ-1.

Molecule	Effect on PARK7/DJ-1	Tissue or Cell Type	Refs.
Negative regulators of PARK7/DJ1
H2O2	Overoxidation	Human brain	[80,81]
p53	Reduced expression	mouse embryonic fibroblasts	[91]
BAG5	Decreased stability	HEK293 human embryonic kidney	[92]
MMP-3	Proteomic fragmentation	CATH.a mouse neuronal	[93]
LPS	Reduced expression	HT-29 human colonic adenocarcinoma	[11]
TNF-α	Reduced expression	HT-29 human colonic adenocarcinoma	[11]
TGF-β	Reduced expression	HT-29 human colonic adenocarcinoma	[11]
miR-128-3p	Reduced expression	Human hepatocellular carcinoma	[94]
miR-494	Reduced expression	3T3-L1 mouse adipocytes and Neuro-2a neuroblastoma	[96]
miR-203	Reduced expression	SW1990/DDP human pancreatic cancer cells	[95]
Positive regulators of PARK7/DJ1
STAT5A	Increased expression	human leukemic pre-B	[97]
SG2NA	Protection from degradation	Neuro2a neuroblastoma	[99,100]
IL-17	Increased expression	HT-29 human colonic adenocarcinoma	[11]
H2O2	Increased expression	HT-29 human colonic adenocarcinoma	[11]