Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 17;23(12):6749. doi: 10.3390/ijms23126749

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Sex effects of Lox^+/C285F. (A), Female C57 Lox^+/C285F show no increase in diameter at 6 months relative to 3 months and only begin to show dilation by 12 months (* p values for 3 vs. 12-month C57 Lox^+/C285F and ^ p values for 6 vs. 12-month C57 Lox^+/C285F by two-way ANOVA, Tukey). (B,C), When bred to HBP, SBP was modestly increased ((B), p < 0.001 for blood pressure effect and p < 0.01 for Lox effect, two-way ANOVA, Sidak) but there was no HBP effect on vessel diameter (C, p = NS for HBP effect and p < 0.001 for Lox effect by two-way ANOVA, Tukey), * shown are for C57 Lox^+/C285F vs. C57 Lox^+/+ and HBP Lox^+/C285F vs. HBP Lox^+/+. There are no statistical differences in diameter within Lox genotypes. (D,E), Male HBP mice (Lox^+/C285F and Lox^+/+) were castrated at P20 and assessed for SBP and aortic diameter at 3 months. SBP was lower in the castrated males ((D), p < 0.05 by one-way ANOVA, Dunn), and aortic diameter was comparable to the nondilated HBP Lox^+/C285 female (E). p values shown are between the sham males and either the castrated males (*) or females (^). For castrated male HBP Lox^+/C285F vs. female HBP Lox^+/C285F p = NS. All female HBP Lox^+/C285F are equivalent. *^, ^ p < 0.05; **^, ^^ p < 0.01; ***^, ^^^ p < 0.001; ****^, ^^^^ p < 0.0001.