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. 2022 Jun 17;23(12):6749. doi: 10.3390/ijms23126749

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Increased elastic lamellar breaks in Lox^+/C285F mice. (A), EVG staining of 6-month C57, and HBP Lox^+/C285 aortas revealed largely intact but disorganized elastic lamellae. Enlarged insert in (A) demonstrates the presence of breaks in Lox^+/C285F. (B–D), Quantification of the number of lamella (B), breaks (C), and wall thickness (D) in Lox^+/+ and Lox^+/C285F mice under both C57 and HBP backgrounds showed an increasingly disorganized and thick vascular wall, most obvious in the 6-month HBP Lox^+/C285F (Lox effect p < 0.0001, age effect p < 0.05 and HBP effect <0.001, multivariable regression, see Supplemental Table S1. * p < 0.05; ** p < 0.01; **** p < 0.0001.