Figure 8.

Elastin and collagen content in Lox^+/C285F mice. (A,B), When bathed in porcine elastase and mechanically stressed, the Lox^+/C285F ascending aorta (A) and left common carotid (B) arteries dilated at a faster rate than WT ((A,B) by two-way ANOVA, Sidak). * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001. (C), Increased amount of elastase was seen in the aortas of Lox^+/C285F mice, indicating the role of elastase in aortic dilation under Lox deficiency. (D), Graph shows the quantification of elastase of all measured samples using total protein as normalization. (Paired t-test) ** p < 0.01.