Table 1.
The characteristics of the studied population and comparison between patients with a lower limb HJHS < 10 (group 1) and a lower limb HJHS ≥ 10 (group 2) (t-tests for independent variables or Mann–Whitney tests).
| Patients with Moderate Haemophilia (n = 24) | Group 1 (n = 16) |
Group 2 (n = 8) |
p | |
|---|---|---|---|---|
| Haemophilia A/B (n) | 15/9 | 8/8 | 7/1 | 0.08 a |
| Level of clotting factor, % (mean ± SD) (min–max) | 3.0 ± 1.0 (1.0–5.0) |
3.1 ± 0.9 (2.0–5.0) |
2.8 ± 1.3 (1.0–4.5) |
0.57 |
| Age, years (mean ± SD) (min–max) | 44.3 ± 16.1 (20–72) |
42.8 ± 16.2 (20–72) |
47.4 ± 16.7 (25–65) |
0.67 |
| Weight, kg (mean ± SD) (min–max) | 75.9 ± 15.0 (48.0–112.0) |
73.8 ± 15.5 (48.0–112.0) |
75.7 ± 7.7 (65.0–85.0) |
0.52 |
| Height, cm (mean ± SD) (min–max) | 173.0 ± 6.6 (160.0–185.0) |
173.3 ± 6.5 (164.0–185.0) |
172.6 ± 7.3 (160.0–182) |
0.95 |
| Body mass index, kg/m2 (mean ± SD) (min–max) | 25.30 ± 4.9 (18.0–38.8) |
24.6 ± 5.2 (18.0–38.8) |
26.8 ± 3.9 (22.0–35.1) |
0.17 |
| Total HJHS (mean ± SD) (min–max) | 10.4 ± 14.0 (0–56) |
2.9 ± 3.5 (0–9) |
22.3 ± 11.3 (11–41) |
<0.0001 |
| Lower limb HJHS (mean ± SD) (min–max) | 9.0 ± 11.1 (0–41) |
2.7 ± 3.4 (0–9) |
18.5 ± 6.8 (10–41) |
<0.0001 |
| Knee HJHS sub-score (mean ± SD) (min–max) | 3.0 ± 4.2 (0–16) |
1.4 ± 1.8 (0–6) |
6.1 ± 5.8 (0–16) |
0.03 |
| Ankle HJHS sub-score (mean ± SD) (min–max) | 4.4 ± 6.7 (0–22) |
0.7 ± 1.4 (0–4) |
11.8 ± 7.0 (2–22) |
<0.0001 |
| Pettersson knee sub-score (mean ± SD) (min–max) | 2.0 ± 2.3 (0–7.5) |
1.7 ± 2.0 (0–7.5) |
2.6 ±2.8 (0–7.0) |
0.61 |
| Pettersson ankle sub-score (mean ± SD) (min–max) | 3.3 ± 3.8 (0–12) |
1.3 ± 1.5 (0–5.5) |
7.5 ± 3.6 (2.5–12) |
<0.0001 |
a Kruskall–Wallis test for the qualitative variable.