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Inhibition of PERK kinase activity partially impairs stiffness-dependent cellular adaptation. GG16-WT cells were treated with GSK414 for 6 days while growing on hydrogels with increasing stiffness. (A) Cells were stained for FLNA and F-Actin and imaged with confocal microscopy. (B–D) Quantified FLNA, F-Actin expression, and cell elongation. * p ≤ 0.05; *** p ≤ 0.001.
