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. 2022 Jun 13;23(12):6586. doi: 10.3390/ijms23126586

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Voluntary task outcomes. Data are shown only for rats performing the task immediately before the time of tissue collection (TASK and TASK+MT). (A) Mean reach rate (mean reaches per minute) across weeks. (B) Mean pulling force on the lever bar across weeks. (C) Mean grasp duration (mean time rat spent holding the lever bar) across weeks. (D–F) Mean reach rate, mean pulling force, and mean grasp duration, respectively, shown for selected days (the four sessions of each day were averaged) and weeks (1, 3, 6, 9, and 12). Abbreviations: 12-week TASK rats (TASK); TASK rats that simultaneously received manual therapy for 12 weeks (TASK+MT). Mean ± 95% confidence intervals (CIs) shown. * and **: p < 0.05 and p < 0.01, respectively, compared to TASK group.