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Effect of compound 4 on the invasiveness of the HOS cells. The cells were treated with the compound at the indicated concentrations for 24 h. The cell invasiveness was determined by means of the BME-coated transwell assay. The results are mean values ± SD of at least three independent experiments. Statistically significant differences: ***—at p < 0.001 in comparison with the untreated cells (one-way ANOVA followed by Dunnett’s post-hoc test).
