Table 3.

Selected pharmacokinetic parameters of compounds 1–7 calculated with the SwissADME tool [http://www.swissadme.ch/, accessed on 15 February 2022].

Compounds	BBB Permeant	GI Absorption	P-gp Substrate	Inhibitor of the Cytochrome P450 Isoenzymes
				CYP1A2	CYP2C19	CYP2C9	CYP2D6	CYP3A4
1	Yes	High	Yes	No	No	No	Yes	No
2	Yes	High	No	No	No	No	No	Yes
3	Yes	High	No	No	No	No	No	No
4	No	High	Yes	No	Yes	No	No	No
5	Yes	High	Yes	No	No	No	Yes	Yes
6	Yes	High	Yes	No	No	No	Yes	Yes
7	Yes	High	Yes	No	No	Yes	Yes	Yes