Table 1.

5-HT₁R-targeted pharmacological agents which have potential effects on ASD treatment.

Names	Structures	Targets	Effects
8-OH-DPAT [24,38,44,48,49]		5-HT1AR/5-HT7R agonist	Increased stereotypic behavior and impaired social interaction via the disruption of sensory processing; enhanced dendritic spine and synapse formation; rescued sociability deficits, anxiety and hyperactivity with DBS treatment
CGS-12066B [38]		5-HT1BR agonist	Increased stereotypic behavior and impaired social interaction via the disruption of sensory processing
WAY-100635 [38]		5-HT1AR antagonist	Slightly alleviate stereotypic behavior in the presence of SSRI
GR-127935 [38]		5-HT1BR antagonist	Slightly alleviate stereotypic behavior in the presence of SSRI
Sumatriptan [39]		5-HT1DR agonist	Reduce repetitive behavior via an increase of growth hormone
F15599 [40]		5-HT1AR agonist	Anti-aggressive effects and reduction of social interaction and an increase of motor inactivity
F13714 [40]		5-HT1AR agonist	Anti-aggressive effects and reduction of social interaction and an increase of motor inactivity
F17464 [41]		5-HT1AR partial agonist/D3R antagonist	Increases dopamine release, rescues impaired social interaction
Aripiprazole [10,11,12,13,14]		Affinity to 5-HT1AR/5-HT2AR/5-HT2BR/5-HT7R; D2R/D3R/D4R	Irritability amelioration
Lurasidone [10,11,12,13,14]		5-HT2AR/5-HT7/D2R antagonist; 5-HT1AR partial agonist	Irritability and aggressive behavior amelioration
RU24969 [45]		5-HT1BR agonist	Induce autism-like behavior including a decrease in social interaction
Vortioxetine [50]		5-HT1AR/5-HT1BR agonist/inhibitor for SERT	Transiently suppress repetitive behavior and enhance social interaction