Table 2.

5-HT₂ receptors-targeted pharmacological agents which have potential effects on ASD treatment.

Names	Structures	Targets	Effects
Olanzapine [60]		5-HT2AR/5-HT2CR/D2R antagonist	Irritability amelioration
Paliperidone [61]		5-HT2AR antagonist	Significant improvement in irritability
Cariprazine [62]		5-HT2AR/5-HT2BR antagonist, 5-HT1AR/D2R/D3R partial agonist	Alleviation of ASD core behavioral deficits
M100907 [63,64,65,66]		5-HT2AR antagonist	Improvement of probabilistic reversal learning; reduced repetitive behaviors
Ketanserin [67]		5-HT2AR/H1R antagonist	Enhanced strategy-switching between a visual cue and response strategy
25CN-NBOH [68]		5-HT2AR agonist	Impairment of probabilistic reversal learning
DOI and SER-082 [68]		DOI: 5-HT2AR/5-HT2CR agonist; SER-082: 5-HT2BR/5-HT2CR antagonist	DOI alone did not impair reversal learning; co-treatment of DOI with SER-082 impair reversal learning
Psilocybin [71]		5-HT2AR agonist	Rescued the social behavioral abnormalities
SB242084 [67,72]		5-HT2CR antagonist	Rescued social behavior deficits