Table 3.
Trials testing novel agents targeting RET fusions in NSCLC.
| NCT Number | Gene Alteration | Experimental Drug | Phase | Study Design | Current Status |
|---|---|---|---|---|---|
| NCT04683250 | RET alterations | TAS0953/HM06 | 1/2 | Sequential assignment | Recruiting |
| NCT03784378 | RET mutation | RXDX-105 | 1 | Single group assignment | Completed |
| NCT03780517 | RET alterations | BOS172738 | 1 | Sequential assignment | Active, not recruiting |
| NCT04161391 | RET fusion, mutation | TPX-0046 | 1/2 | Single group assignment | Recruiting |
| NCT01877811 | RET rearrangement, fusion | RXDX-105 | 1 | Single group assignment | Completed |