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. 2022 Jun 10;23(12):6501. doi: 10.3390/ijms23126501

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Combination treatment of sorafenib and orlistat changes the expressions of fatty acid synthesis-related and AMPK/mTOR-related proteins in (A) Huh7 and (B) Huh7/SR cells. Combination treatment caused reductions in FASN and SCD and increased pACC expression in both cell lines. Besides, the combination treatment activated the AMPK/mTOR pathway only in Huh7 cells but not in Huh7/SR cells. a, compared to Control; b, compared to Sorafenib; c, compared to Orlistat; ¹ p < 0.05; ² p < 0.01; ³ p < 0.001.