Table 1.
miRNAs upregulated in OC cells that contribute to tumor growth and development, angiogenesis, and therapeutic resistance.
| miRNA | Target mRNA(s)/Function | Ref |
|---|---|---|
| miR-21 | APAF1/Promotes angiogenesis and treatment resistance (paclitaxel) | [131,132] |
| miR-22 | MXI1/Promotes tumor growth | [133] |
| miR-27a | VEGF/Promotes VEGF expression to promote angiogenesis | [123] |
| miR-30a | FOXD1/Promotes cell cycle progression and growth | [134] |
| miR-92a | DKK1/Promotes Wnt signaling and tumor growth | [135] |
| miR-99a | FN1, VTN/Promotes tumor metastasis | [136] |
| miR-106a | CASP7/Promotes treatment resistance (paclitaxel) | [137] |
| miR-141 | p38α, KEAP1/Promotes tumor growth and treatment resistance (cisplatin) | [121,138] |
| miR-181a | SMAD7/Promotes tumor growth, angiogenesis, and treatment resistance | [139] |
| miR-182 | MTSS1, PDCD4/Promotes tumor growth, metastasis, and treatment resistance (cisplatin and paclitaxel) | [140,141,142] |
| miR-200a | p38α/Promotes tumor growth | [121] |
| miR-203 | PDHB/Promotes cell proliferation | [143] |
| miR-204 | THBS1/Promotes angiogenesis and tumor growth | [126,127] |
| miR-205 | SMAD4, PTEN/Promotes metastasis and angiogenesis | [144] |
| miR-210 | PTPN1/Promotes survival and evasion of cell death mechanisms | [145] |
| miR-214 | PTEN/Promote cell survival and treatment resistance (cisplatin) | [146] |
| miR-223 | PTEN/Promote tumor growth and treatment resistance (cisplatin) | [147] |
| miR-376a | KLF15/Promotes cell cycle progression and growth | [148] |
| miR-443 | MAD2/Promote tumor growth and treatment resistance (paclitaxel) | [149] |
| miR-551b | STAT3/Promotes tumor growth | [150] |
| miR-552 | PTEN/Promotes tumor metastasis | [151] |
| miR-622 | KU70, KU80/Promotes treatment resistance (cisplatin and PARP Inhibitors) | [152] |
| miR-939 | APC2/Promotes Wnt signaling and tumor growth | [153] |
| miR-1246 | CAV1/Promotes treatment resistance (paclitaxel) | [154] |