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. 2022 Jun 9;23(12):6473. doi: 10.3390/ijms23126473

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Anti-tumor immunity is boosted in patients with higher RvD scores. (A) IPA findings of biological functions associated with higher resolution scores. The most significantly affected molecular, cellular and biological functions and their relative p-value in patients with higher versus lower resolution scores are shown. (B) Activation z-score of biological functions related to cell movement. Each square reports the activation z-score (color legend is reported in the inset, sized by -log p-value) for the described biological functions. (C) Activation z-score of biological functions related to activation. Each square reports the activation z-score (color legend is reported in the inset, sized by -log p value) for the described biological functions. (D) Predicted tumor infiltration of 10 human immune subsets in HNSC samples with a high (n = 100) or low (n = 100) RvD score, as inferred by CIBERSORT. * p < 0.05; ***, p < 0.001; **** p < 0.0001, two-way ANOVA and Sidak’s multiple comparisons test. (E,F) Differentially expressed genes and significantly associated biological functions (Fx) related to activation (E) and response (F) of leukocytes.