Table 2.
PRISMA resulting conceptual skeleton structure of the article’s organization approach.
| Physiological Properties of H2S | ||
|---|---|---|
| Authors | Ref. No. | Subject-Data |
| (Sun, 2021) | [3] | An Updated Insight Into Molecular Mechanism of H2S in Cardiomyopathy |
| (George, 2018) | [6] | Treating inflammation and oxidative stress with H2S during age-related macular degeneration |
| (Zou, 2017) | [10] | H2S ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats |
| (Rey, 2021) | [11] | Mitochondrial metabolism as target of the neuroprotective role of erythropoietin in Parkinson’s disease. |
| (Testai, 2021) | [12] | Modulation of EndMT by H2S in the Prevention of Cardiovascular Fibrosis |
| (Ciccone, 2021) | [13] | Endothelium as a Source and Target of H2S to Improve Its Trophism and Function |
| (Wu, 2017) | [16] | Exogenous H2S facilitating ubiquitin aggregates clearance via autophagy |
| (Hu, 2017) | [20] | Chelerythrine Attenuates Renal Ischemia/Reperfusion-induced Myocardial Injury |
| (Kar, 2019) | [22] | H2S -mediated regulation of cell death signaling ameliorates adverse cardiac remodeling |
| (Jeong, 2020) | [24] | Protective effect of H2S on oxidative stress-induced neurodegenerative diseases |
| (Luo, 2019) | [25] | H2S upregulates renal AQP-2 protein expression and promotes urine concentration |
| (Yang, 2019) | [26] | Exogenous H2S mitigates myocardial fibrosis through suppression of Wnt pathway |
| (Liu, 2018) | [27] | H2S attenuates myocardial fibrosis through the JAK/STAT signaling pathway |
| (Sun, 2019) | [28] | Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes |
| (Roa-Coria, 2019) | [29] | Possible involvement of peripheral TRP channels in the H2S-induced hyperalgesia |
| (Yang, 2017) | [30] | Exogenous H2S regulates endoplasmic reticulum-mitochondria crosstalk to inhibit apoptosis |
| (Zhao, 2021) | [31] | H2S Plays an Important Role in Diabetic Cardiomyopathy |
| (Liu, 2017) | [32] | H2S modulating mitochondrial morphology to promote mitophagy in endothelial cells |
| (Qiu, 2018) | [33] | Alpha-lipoic acid regulates the autophagy of vascular smooth muscle cells elevating H2S level |
| (Li, 2017) | [34] | H2S reduced renal tissue fibrosis by regulating autophagy in diabetic rats |
| (Yu, 2020) | [35] | Exogenous H2S Induces Hrd1 S-sulfhydration and Prevents CD36 Translocation via VAMP3 |
| (Kar, 2019) | [36] | H2S Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction |
| (Dominic, 2021) | [37] | Decreased availability of nitric oxide and H2S is a hallmark of COVID-19 |
| (Loiselle, 2020) | [38] | H2S and hepatic lipid metabolism-a critical pairing for liver health |
| (Ma, 2017) | [39] | Exogenous H2S Ameliorates Diabetes-Associated Cognitive Decline |
| (Jiang, 2020) | [40] | H2S Ameliorates Lung Ischemia-Reperfusion Injury Through SIRT1 Signaling Pathway |
| (Wu, 2019) | [41] | H2S Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux |
| Pathophysiological Properties H2S | ||
| Authors | Ref. No. | Subject-Data |
| (Citi, 2021) | [7] | Role of H2S in endothelial dysfunction: Pathophysiology and therapeutic approaches |
| (Kang, 2020) | [14] | H2S as a Potential Alternative for the Treatment of Myocardial Fibrosis |
| (Sun, 2019) | [42] | H2S and Subsequent Liver Injury |
| (Szabo, 2017) | [43] | Pharmacological Modulation of H2S Levels |
| (Sun, 2020) | [44] | The Link Between Inflammation and H2S |
| (Zheng, 2020) | [45] | H2S protects against diabetes-accelerated atherosclerosis by preventing the activation of NLRP3 |
| (Jia, 2020) | [46] | H2S mitigates myocardial inflammation by inhibiting nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation in diabetic rats |
| (Li, 2017) | [47] | H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-beta 1 expression |
| (Kar, 20190 | [48] | Exercise Training Promotes Cardiac H2S Biosynthesis and Mitigates Pyroptosis |
| (Li, 2019) | [49] | Exogenous H2S protects against high glucose-induced apoptosis and oxidative stress |
| H2S—Role in Diabetes Mellitus and Associated Vascular Pathology | ||
| Authors | Ref. No. | Subject-Data |
| (Gheibi, 2020) | [8] | Regulation of carbohydrate metabolism by NO and H2S: Implications in diabetes |
| (Zhang, 2021) | [50] | H2S regulates insulin secretion and insulin resistance in diabetes mellitus |
| (Chen, 2021) | [51] | Role of H2S in the Endocrine System |
| (Gheibi, 2019) | [52] | Effects of H2S on Carbohydrate Metabolism in Obese Type 2 Diabetic Rats |
| (Luo, 2017) | [53] | The Role of Exogenous H2S in Free Fatty Acids Induced Inflammation in Macrophages |
| (Comas, 2021) | [54] | The Impact of H2S on Obesity-Associated Metabolic Disturbances |
| (Suzuki, 2017) | [55] | Clinical Implication of Plasma H2S Levels in Japanese Patients with Type 2 Diabetes |
| (Zhou, 2019) | [56] | H2S Prevents Elastin Loss and Attenuates Calcification Induced by High Glucose |
| H2S—As a Natural Therapeutic Factor in DM | ||
| Authors | Ref. No. | Subject-Data |
| (Melino, 2019) | [2] | Natural H2S Donors from Allium sp. as a Nutraceutical Approach in Type 2 Diabetes |
| (Sashi, 2019) | [5] | H2S inhibits Ca2+-induced mitochondrial permeability transition pore opening |
| (Yang, 2017) | [21] | H2S Releasing/Stimulating Reagents |
| (John, 2017) | [57] | GYY4137, an H2S Donor Modulates miR194-Dependent Collagen Realignment |
| (Bitar, 2018) | [58] | H2S Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes |
| (Ding, 2017) | [59] | High Glucose Induces Mouse Mesangial Cell Overproliferation via Inhibition of H2S Synthesis |