Table 2.
Elimination rate constants (kelim, h−1) in the brain, the right lung and the left kidney of the three mouse strains before and after treatment with thiethylperazine.
| Group | Scan | Brain (h−1) | Lung (h−1) | Kidney (h−1) |
|---|---|---|---|---|
| Wild-type | Baseline | 1.39 ± 0.05 | 1.26 ± 0.29 | 1.54 ± 0.31 |
| Thiethylperazine | 1.36 ± 0.05 | 1.13 ± 0.24 | 1.72 ± 0.28 | |
| APP/PS1-21 | Baseline | 1.44 ± 0.11 | 1.26 ± 0.18 | 1.56 ± 0.43 |
| Thiethylperazine | 1.43 ± 0.19 | 1.23 ± 0.22 | 1.54 ± 0.28 | |
| Abcc1(−/−) | Baseline | 0.14 ± 0.01 | 0.30 ± 0.09 | 0.40 ± 0.45 |
| Thiethylperazine | 0.18 ± 0.04 | 0.39 ± 0.23 | 0.61 ± 0.30 |
All data are given as mean ± SD.