Figure 2.

A1, A2, Sample recorded excitability traces from WT and R6/2 VAL neurons (left) and summary plot of input-output mean number of spikes at 21 and 75 d. B1, B2, Sample recorded excitability traces from WT and R6/2 VPM neurons (left) and summary plot of input-output mean number of spikes at 21 and 75 d. Thalamic neurons fired action potentials when injected with a suprathreshold current pulse. Injected current pulses (1 s) started from the resting membrane potential (Vm) and were increased in steps of 25 pA. Statistical significance was determined using two-way ANOVAs followed by Bonferroni post hoc tests; *p < 0.05, **p < 0.01.